Antimicrobial Resistance Patterns of Outpatient Staphylococcus aureus Isolates
SUMMARY
JAMA Network Open | 14 June 2024
A retrospective analysis of 382,149 Staphylococcus aureus isolates from U.S. Veterans Health Administration outpatients reveals significant shifts in antimicrobial resistance patterns over a 10-year period. While the proportion of methicillin-resistant S. aureus (MRSA) decreased nationwide, researchers observed concerning increases in resistance to tetracyclines and trimethoprim-sulfamethoxazole, particularly in the southern United States.
The study's geographical analysis uncovered regional variations in resistance rates, highlighting the importance of understanding local trends to guide empirical antibiotic prescribing practices. These findings underscore the critical need for healthcare professionals worldwide to consider regional spatial variations in antibiotic resistance when making prescribing decisions, as such insights can inform empirical therapy recommendations and contribute to better understanding the evolution of S. aureus antibiotic resistance mechanisms globally.
FEATURED EXPERTS
Margaret Carrel, PhD, Department of Geographical and Sustainability Sciences, University of Iowa, USA
Matthew Smith, MD, MPH, Department of Internal Medicine, University of Iowa, USA
Qianyi Shi, PhD, Center for Access & Delivery Research and Evaluation, Iowa City Veterans Affairs HealthCare System, USA
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This 10-year AMR research makes the case for improved geographical surveillance and local resistance monitoring.
PUBLISHED BY
August 2024
